What are the Causes and Treatments of Cellulitis? - Cellulitis can develop anywhere on a person’s body, but it mostly affects the skin of the lower legs. In severe cases, the infection can spread to lymph nodes and bloodstream, which can be quite painful. If cellulitis is not diagnosed on time, it can be life-threatening. Keeping in mind the serious nature of cellulitis, it is especially important to know the symptoms, causes, and treatments of this condition.