Lab-Grown vs. Natural Gemstones: A Comparative Analysis Generally, when people ask which is a better choice between natural and lab-grown gemstones, honestly, the answer depends on one's priorities. If you're looking for affordable gems, you must go for lab-created gems, whereas if you're seeking something earthy, precious, and rare with therapeutic healing significance, go for Natural Gemstones. No matter which type you choose, it is important to have an idea about both of them so that you can differentiate and make an informed decision.