Supatret 0.04 microsphere Gel contains tretinoin, a vitamin A derivative. By clearing skin pores and preventing spots or pimples from forming, it helps treat acne. By clearing skin pores and preventing the emergence of spots or pimples, Supatret Gel 0.04% - Tretinoin Microsphere Gel is a topical drug that helps in the treatment of acne. By clearing skin pores and preventing the emergence of spots or pimples, Supatret Gel 0.04% - Tretinoin Microsphere Gel is a topical drug that helps in the treatment of acne.