Simparica Trio is an advanced version of Simparica. It provides powerful triple protection against fleas and ticks, intestinal worms, and deadly heartworm disease, all in a tasty monthly chew. The tasty, liver-flavoured oral chew contains a specially optimised trio of ingredients for proven efficacy against multiple parasites. Simparica Trio kills fleas before they lay eggs and controls flea allergy dermatitis. It begins killing fleas within just 4 to 8 hours after treatment.